50 tabs contains 10 mg Methandienone
Pharmaceutical Name: Methandrostenolone / methandienone
Chemical Names: 17a-methyl-17b-hydroxy-1, 4-androstadien-3-one 1-Dehydro-17a-methyltestosterone methandienone
Molecular Weight: 300.44
Melting Point: 159-164 degrees Celsius
Active Life: 3-8hours
Detection Time: up to 6 weeks
Anabolic/Androgenic Ratio (Range): 90-210:40-60
Methandrostenolone has long been a favourite of strength athletes and bodybuilders since it's creation in 1956, with the explicit purpose of it's creation being for the use by athletes. It was the compound's ability to promote drastic protein synthesis, stimulate strength in a direct and fast-acting way, and it's ability to enhance glycogenolysis that made it so popular, and why it's popularity remains high today.
In terms of it's medical use, methandrostenolone was/is used in the treatment of conditions such as interstitial-pituitary insufficiency, chronic adrenocortical insufficiency, thyrotoxicosis, diabetic angiopathies (retinopathy and nephropathy), steroidal diabetes, and pituitary dwarfism among others (1). However, due to the U.S. Food and Drug Administration's belief that the compound was being used inside of the bodybuilding community far more than in the treatment of medical conditions, it ordered that American companies discontinue it's manufacture in the early 1990's. Numerous drug companies outside of U.S. borders continue to make the drug however, and it's prevalence on the black market has remained very high.
It can be concluded that the best use for methandrostenolone is short-term with most users prefering to use the product for between four to six weeks, although some will prolong the use with limited consequences to health, despite its strong hepatoxic effects. For the most part, most recreational users begin admistering methandrostenolone at the start of a longer bulking stack to "jumpstart" gains in mass and strength. However, it's use prior to various sorts of competitions is also quite common so that it's effects are realized during a specific period.
Due to the active life, which is three to eight hours, multiple doses throughout the day of methandrostenolone should be utilized. It is best to maintain bloodlevels as evenly as possible, therefore dividing doses throughout the day at even amounts is required. Some argue that administration of the drug should cease a few hours before you sleep as it will cause further HPTA shut down, as the body's natural testosterone production during sleep could be affected. However, if you are taking other compounds along with methandrostenolone, these will already be shutting down your natural testosterone production, therefore this is not a concern.
In terms of dosing, it has been reported that doses of 10 mg can increase androgen activity by five times, as well as have an effect of a 50 to 70% decrease in cortisol activity (2). Despite this, the majority of anecdotal evidence suggests that twenty to forty milligrams is the norm in terms of first time users (as ascertained from the anecdotal knowledge gleamed from various users). However, doses ranging from 100-150mg and higher have been reported by some experienced users. As with the majority of ananbolic drugs, the returns are seemingly diminished and the likelihood of side effects increase as the doses do.
Similar to nearly all oral steroids, the vast majority of users will recognize the fact that methandrostenolone should not be run alone and only stacked with other compounds. This is due to the fact that most users who have run methandrostenolone only cyles have reported anecdotally that it is extremely difficult to maintain gains post cycle. However, the same is true when discontinuing the drug and having your other compounds "kick in", if they are long ester. It is often the case that the water retention experienced while on methandrostenolone will be shed but the gains in strength and mass will remain due to the other compounds being present. It can be argued that therefore, the gains experienced while on methandrostenolone are short lived no matter what the circumstances and the compound should only be used as a quick fix for either competition or else simply as a motivator while waiting to notice the effects of long estered compounds. However, others will argue that the gains they make while using the compound are indeed maintainable. Therefore, personal experimentation is once again the only way to see how an individual reacts.
Estrogenic side effects can be a concern with methandrostenolone, as it converts to estradiol via aromatase, although this is quite modest at best. High blood pressure, water retention, gynocomastia, and acne are all possible undesireable side effects during use of methandrostenolone. As an aside, a high number of users have also reported experiencing nose bleeds while using the compound. Some attribute this to an increase in blood pressure, while others have not noticed a rise in their blood pressure but still experience an increase in the number of nose bleeds they have while using methandrostenolone.
Use of an aromatase inhibitor such as armidex or estrogen blocker such as nolvadex should help to counteract some of these side effects. As for potential hair loss, the androgenic metabolite 5-alpha dihydromethandrostenolone is only produced in trace amounts, and therefore hairloss should not be a concern(3). In women it is not uncommon for virilizing side effects to occur, including increased growth of androgen-sensitive hair and deepening the voice, amongst others. There are no ways to minimize these side effects in women if they are experienced other than to keep the dosage that one is taking to a minimum.
Like most oral steroids methandrostenolone is 17-alpha-alkylated so that it can't be broken down into a 17-ketosteroid, and therefore rendering the substance ineffective. However, this causes liver values to become elevated over a short period of time. It is for this reason that long-term use of any 17-alpha-alkylated steroid is considered dangerous. Despite this however, no long-term damage should be expected if use is kept to relatively short periods, with liver values returning to previous levels after use is discontinued in nearly all cases (4).
It should also be noted that methandrostenolone may be less useful to those competing in aerobic events as it also diminishes cell respiration(5). This may inhibit an individual's ability to perform at their maximum capacity.